Development of Benzylic-Substituted Ligands for Asymmetric Catalysis

Ion-paired chiral ligands for asymmetric palladium catalysis.

Conventional chiral ligands rely on the use of a covalently constructed, single chiral molecule embedded with coordinative functional groups. Here, we report a new strategy for the design of a chiral ligand for asymmetric transition-metal catalysis; our approach is based on the development of an achiral cationic ammonium-phosphine hybrid ligand paired with a chiral binaphtholate anion. This ion...

Novel Bis-1,3,2-diazaphospholidine Ligands for Asymmetric Catalysis

A family of modularly designed chiral bis-1,3,2-diazaphospholidines with N-aryl substituents (NP-PN) is reported. These compounds have been prepared in two steps from readily available (R,R)-1,2-diaminocyclohexane and tetrachlorodiphosphines. Examples in the set differ in the backbone and the aryl substituents aiming at their application in asymmetric catalysis. Thus, [Rh(NBD)(NP-PN)]BF4 comple...

New Applications of Tridentate Bis(oxazoline) Ligands in Asymmetric Catalysis

Finding interactions between microRNAs and their mRNA targets is a challenging experimental and computational problem. While several novel experimental high throughput approaches have been developed for measuring miRNA expression, the amount of data generated from these technologies is dwarfed by the amount of data existing in current gene expression microarray repositories. Many microRNAs over...

Chiral olefin ligands-new "spectators" in asymmetric catalysis.

Ferrocene phosphane-heteroatom/carbon bidentate ligands in asymmetric catalysis.

Chiral ferrocene derivatives belong to privileged ligand classes for asymmetric transition metal catalysed reactions. Hetero-bidentate phosphane ligands are hybrid ligands, which combine the properties of phosphorus with those of other donor atoms. This feature creates further asymmetry around the metal centre, which may be helpful for increasing the stereoinduction. Therefore, hetero-bidentate...